Word: hiv
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Dates: during 1990-1999
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...group's research, published in an article in Science entitled "Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Nucleoside-Analog Drug Resistance," represents years of efforts aimed at understanding...
According to Harrison, when HIV enters a human cell, it uses RT and RNA to form a new strand of viral DNA. Then this strand is used to make another one,which when joined with the first, forms the fameddouble helix...
...moment at which a nucleotide is added isimportant because it is the same instant at whichmany HIV drugs inhibit RT--or fail to, if RT hasmutated...
...inhibitors attempt to act as a stop valve,inserting defective nucleotides that are unable tobind with other molecules, thus ending the growthof a new chain of DNA and preventing thereproduction of HIV...
Getting a freeze frame of the mechanism was anextremely difficult task because of the alarmingrate at which HIV grows, Harrison said...