Word: hiv
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Dates: during 1990-1999
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...Africa when that was happening. Now Big Industry smells a potential market in the "rising African countries," and here is Clinton to pave the way. But how can you talk of a renaissance in Africa when in Zimbabwe a sizable percentage of the people between 20 and 30 are HIV positive? VOLKER DOLITZSCH Steffisburg, Switzerland...
Vertex's first major research effort--designing a safe and reliable inhibitor for the HIV protease that assists with the replication of the HIV virus--started with generating a molecular map of the protease enzyme...
Vertex scientists solved the structure in 1992 (see picture below) and began to explore several potential sites for artificial blockage, using supercomputers to suggest possible "keys" for the HIV "lock." In practice, the computer's guess is often far from perfect, but computers can help bench-top scientists refine their search for the molecule with the perfect...
Vertex scientists attacked the HIV protease with different drug candidates, using combinatorial chemistry to produce thousands of subtle variations of the computer's best guess. Combinatorial chemistry, explains Harvard Professor of Chemistry Gregory L. Verdine, "is a technology that allows one to make thousands to millions of organic compounds of defined structures in a very rapid period of time...
...uncovers a scoring error from earlier this season that means University of Connecticut star Nykesha Sales, awarded a controversial two-point gimme shot last month, is still short of the school record. And its well-written feature stories include an alarming profile of former heavyweight Tommy Morrison, who is HIV positive and refuses treatment...