Word: hiv
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Dates: during 2000-2009
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This is a finding five years in the making. Virologist Robin Weiss of University College London began to study the relevant receptor in 2003, after seeing earlier research that showed how variation in another gene similarly blocked the receptor that allows HIV to enter white blood cells; far fewer people carry that variant. In the lab, Weiss found that the African-specific receptor, called DARC, or duffy antigen receptor for chemokines, also interacted with HIV: the receptor binds to a wide array of proteins that suppress the virus's replication. Intrigued, but unable to explain why the lack...
...turned out that among a select cohort of American military personnel who had been followed over decades, the roughly 1,200 carriers of the trait, all of whom were African-American, were 40% more likely after adjustments to be infected with HIV than noncarriers. From that sample, Weiss and his colleagues extrapolated the infection risk attributable to the gene variant in Africa, where a 40% increased susceptibility to infection translates to about 11% of all infections...
There's no doubt Africans have borne the brunt of the AIDS epidemic. Now researchers in London and Texas say it may have something to do with a single gene variant that could account for 11%, or about 2.5 million, of Africa's HIV cases...
...blood-cell receptor, along with two-thirds of African-Americans. But the variant that once saved its carriers from one disease now appears to make them more susceptible to another. According to the paper, people with the gene variant were 40% more likely to become infected with HIV than people without...
Interestingly, among the servicemen who were infected with HIV, those who carried the gene variant lived on average two years longer than noncarriers. "We still can't say exactly why," Weiss says. And though the effect of this gene variant, if confirmed, could help explain a huge number of HIV infections, it still cannot come close to explaining the AIDS burden of Africa. Nearly 70% of all HIV-positive people in the world live in sub-Saharan Africa, and prevalence rates in adults in some African countries top 20%. What's more, the gene variant is most common in West...