Word: hiv
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...School of Public Health, Lagakos founded the Center for Biostatistics in AIDS Research and pioneered new methodologies to estimate life spans for AIDS patients and transmission of HIV from mothers to their children during pregnancy...
...What he taught me to do was to think about pulling together a big collaboration of academic groups and pharmaceutical companies to really validate surrogate endpoints in the HIV setting,” Hughes said...
Fauci acknowledges that the vaccine's effect is small, but believes that it's an important first step toward understanding how the body fights off HIV. "It's barely significant, yes," he says. "But it's interesting in that it opens up a door for us to be able to pursue more research." Although the number of volunteers who were protected were few, they are still the first who may have been protected at all by an AIDS vaccine and are therefore considered a valuable starting point...
From the outset, the vaccine strategy used in the NIH and U.S. Army study - giving two older vaccines in succession - has been controversial. In previous trials, each vaccine had failed to provide any protection against HIV, and in September 2004 a group of adamant scientists wrote a letter to Science arguing that the National Institute of Allergy and Infectious Diseases should not to continue with the trial. "We seriously question whether it is sensible now to conduct a ... trial that, in our opinion, is no more likely to generate a meaningful level of protection against infection or disease," they wrote...
...results may yet extend to AIDS-vaccine research. The trial was never intended to serve as a demonstration of effectiveness to license a new vaccine, he says. As such, it was a proof-of-concept study that showed it is indeed possible to generate an immune response against HIV - even if only a small...