Word: hiv
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...statistical, rather than empirical, approach yielded some remarkable results, Liu said, citing as an example the combination of mutations found at sites 46, 54, and 82 in the HIV genome...
...said that analysis found that mutations at solely sites 46 or 82 lead to weak resistance to Indinavir, an HIV protease inhibitor, but mutations at site 54 alone have no effect. More surprisingly, mutations at sites 54 and 45 actually made the virus even more susceptible to the drug...
This knowledge could one day help doctors better design drug therapies by allowing them to sequence patients’ viruses and predict which drugs the HIV strain would be the most likely to become resistant to in advance, according to Zhang. Such an application could make treatments much more cost-effective, she added...
...It’s very encouraging that we can identify patterns of resistance so that we can understand something about why these patterns exist,” said Daniel R. Kuritzkes, a professor of medicine at HMS who has conducted extensive research on mechanisms and clinical significance of HIV drug resistance...
...study, which was published on Monday, HIV sequences from both treated and untreated patients were obtained from the HIV Drug Resistance Database, an open access database of reverse transcriptase and protease sequences maintained by Stanford University...