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...which estrogen regulates breast cancer. The findings—to be published in Nature Genetics this month—may help individualize treatment for breast cancer patients and provide additional options for those patients resistant to drugs currently used for treatment, according to the senior author, Harvard Medical School (HMS) Associate Professor of Medicine Myles A. Brown. Estrogen contributes to tumor cell growth via its role in binding to a protein net known as the estrogen receptor (ER), located in the nucleus of 70 percent of breast cancer cells. When estrogen attaches to this receptor, the binding initiates a flurry...

Author: By Aditi Balakrishna, CONTRIBUTING WRITER | Title: Genetic Map Adds to Cancer Research | 10/5/2006 | See Source »

...Children’s Cancer Research Foundation (now known as the Dana-Farber Cancer Institute), and was a research associate in Pathology at the Harvard School of Public Health from 1960-1970, I am appalled at the controversy surrounding the investigation of Professor Chester Douglass (“HMS Defends Review of Dental School Prof,” news, Sept. 19). First of all, it surprises me that someone from the School of Dental Medicine was put in charge of such a sensitive research issue as the possible connection between water fluoridation and bone cancer. Douglass already had a history...

Author: By Samuel S. Epstein, | Title: Harvard Inquiry Into Fluoride Study Problematic | 9/29/2006 | See Source »

...Graduate Medical Education (ACGME), which accredits post-medical school training programs in the U.S., implemented new rules that wisely limited residents to work no more than six days per week, 80 hours per week, and 30 hours per shift. But a report published this month by Harvard Medical School (HMS) researchers found that four out of every five residents had violated the regulations at least once in their first year of residency. With lives at stake, hospitals need to continue to work towards greater compliance with the ACGME rules...

Author: By The Crimson Staff | Title: Bad Medicine | 9/21/2006 | See Source »

...care, from a patient’s admission to her discharge. But hospitals take advantage of residents’ long hours as sources of cheap labor. The results, unfortunately, are dangerous, with an increased risk of accidental needlestick injuries, for example, at the end of a long shift. The HMS researchers, led by Assistant Professor of Pediatrics and Medicine Christopher P. Landrigan, also cite an earlier study that found that “human performance” after staying awake for 24 hours is comparable to human performance of those with a blood alcohol content of 0.10 percent...

Author: By The Crimson Staff | Title: Bad Medicine | 9/21/2006 | See Source »

...decrease wasn’t in absolute compliance with the ACGME’s work limits. But for compliance to further improve, hospitals—including Harvard’s throng of teaching hospitals—should continue to introduce institutional changes that make compliance easier for residents. The HMS report, for example, suggests not requiring residents to work up to the very last minute of their scheduled shift, a situation which often leads to residents working overtime when an emergency occurs near the end of a shift. (Unfortunately, residents can do little to improve their own situations, since reporting...

Author: By The Crimson Staff | Title: Bad Medicine | 9/21/2006 | See Source »

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