Word: hoaglands
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...Bonner, P., sales rep. 292 816 320 840 Honeywell Carlson, E., engineer 240 1000 210 1100 Cleary, M., salesman 365 1728 240 1920 Dushman, B., B.U. student 536 2583 522 2510 Fabiyi, E., trainee, A.D.L. 220 1584 270 780 Hamlen, D., ins't supervisor 490 1500 402 1000 Hoagland, J., vice pres. 320 3000 236 1160 Jones, L., assoc. prof. 415 3225 280 2416 Jones, M., math teacher 362 624 260 1160 Turner, A., librarian 278 840 272 934 Peet, G., planning engineer 403 1584 230 958 Liveson, ay, dr. of neurology 652 2450 450 2100 McCarriston, J., student...
When he got to Honolulu's Tripler General Hospital, reports U.S. Army Surgeon Robert J. Hoagland in the American Journal of Medical Sciences, he discovered that the military community provided him with more than his share of such exasperating emergencies. Anxious to do something about his desperate patients, Dr. Hoagland suggested that emergency-room physicians try to combat coma with doses of "analeptics"-a class of drugs that includes Benzedrine and Dexedrine, and works by stimulating the central nervous system into a state of hyperwakefulness...
Massive Injections. Hoagland's colleagues showed little enthusiasm for the idea. Analeptics, they all said, had been tried on patients in coma before, had proved worthless in some cases, actually harmful in others. They had unpredictable effects on the blood pressure and respiration. Even so, on the basis of animal experiments, Dr. Hoagland thought that one analeptic, methylphenidate (trade name: Ritalin), was worth...
...Hoagland's hunch seemed to pay off. Methylphenidate not only roused would-be suicides from their comas, but it was also effective for patients suffering from coma resulting from brain damage and liver failure. For the first time, such patients were able to swallow food and medication, cough up sputum and mucus, thus avoiding one of coma's worst complications, suffocation...
...Does It Work? Now director of the Army Medical Research Laboratory at Fort Knox, Dr. Hoagland is still not sure how methylphenidate works. Like other analeptic drugs, it may stimulate the subcortical region of the brain and help control general alertness; it also seems to stimulate the respiratory center. But why does methylphenidate appear to be safer than other drugs? Dr. Hoagland suspects that the answers may eventually be traced to the drug's rapid excretion from the bloodstream and into the urine. "But until we understand more about coma," says he, "we cannot hope to understand Ritalin." Meanwhile...