Word: hoffmann
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Dates: during 1990-1999
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...good to be true? You bet your love handles. Developed by New Jersey- based Hoffmann-La Roche, orlistat (chemical name: tetrahydrolipstati n) shows promise, but its effects are strictly limited and still not completely understood. Preliminary studies suggest that when taken in conjunction with a moderate diet, it can reduce fat uptake in seriously overweight patients up to 270 calories a day -- the equivalent of about one scoop of Haagen-Dazs. The drug is not a panacea. Nor is it anything anybody should consider swallowing just to look better in a bikini...
Orlistat, taken three times a day, inhibits fatty buildup but does not completely prevent the enzymes from doing their job. According to Dr. Jonathan Hauptman, director of therapeutic research at Hoffmann-La Roche, the body produces lipase in such quantities that the drug is only about 30% effective, no matter how much of it you ingest. If you took a dose of orlistat and then ate 100 grams of fat (roughly four Big Macs), 70 of those grams would be absorbed as usual and 30 grams would pass, undigested, through the intestine...
Given the uncertainties -- and the hefty premium Hoffmann-La Roche can be expected to charge for any new diet pill -- medical experts say that use of orlistat should generally be limited to those who need it most. Candidates would include the tens of millions of people who suffer from chronic, intractable obesity and the millions more who are only a few binges away from that plight...
...flood of 1993. "There was an eerie normality to life in Des Moines," she says. "With Guardsmen patrolling the empty streets, humidity oppressive and helicopters circling in the sky, it seemed like a M*A*S*H episode." TIME's photographers -- Steve Liss, Ron Haviv, Najlah Feanny and Fritz Hoffmann -- were scouring the area to capture such scenes on film...
...Harvard Facilities Maintenance department called the Cambridge Fire Department, as chemistry department regulations require. The fire department ordered Mallinckrodt evacuated and Oxford Street blocked off from the Science Center to the Hoffmann laboratories, said Henry S. Littleboy, health and safety officer in the faculty of arts and sciences environmental health and safety office...