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...HORIZON Researchers are exploring two related molecules, gaba and glutamate, that are responsible for 90% of chemical signaling in the brain. Because they control so much of the brain's activity, the trick is to fine-tune their levels in ways that relieve depression but don't affect other brain functions. Other targets of drug development: the sex hormone testosterone (a transdermal patch proved effective in a recent clinical trial for men); the stress hormone cortisol, which researchers are trying to regulate with the abortion drug RU 486 and compounds called CRF antagonists; the dynorphins (the evil twins of feel...

Author: /time Magazine | Title: Depression: What You Can Do | 1/20/2003 | See Source »

...HORIZON Researchers are exploring a similar technique that sends an electrical current through the vagus nerve--a major conduit wiring the heart and intestines--which then delivers it to the brain. Another approach, called regional transcranial magnetic stimulation, uses an electric coil shaped like a figure eight to create a magnetic field inside the pre-frontal cortex, which plays a key role in mood regulation...

Author: /time Magazine | Title: Depression: What You Can Do | 1/20/2003 | See Source »

...HORIZON Meditation, mindfulness training and biofeedback have long been championed as proven stress relievers. Now proponents believe these techniques may also provide relief to people with depression by lowering levels of cortisol...

Author: /time Magazine | Title: Depression: What You Can Do | 1/20/2003 | See Source »

...Iraq's treasury. A few trenches have been dug through the desert, where sheep amble peacefully under the watchful eye of haughty Bedouin women. There are some soldiers, but hardly enough to defend the crucial oil fields that burn brightly on the horizon. Along the highway from Basra to Baghdad, the army posts have been freshly whitewashed but are poorly fortified: the walls are low and there are just three men with a machine gun on guard. "If America attacks, only Baghdad will stay," a former soldier admitted after making the usual promises of a do-or-die battle. "There...

Author: /time Magazine | Title: On Saddam's Shaky Frontline | 1/17/2003 | See Source »

...helm doing his best to convince WorldCom's anxious customers and employees that the company, whose revenue has fallen an estimated 15% to 20% in the past year, won't be disconnected anytime soon. Now, with the prospect of a possible fine of up to $9 billion on the horizon, he has to craft a viable reorganization plan for the largest corporate bankruptcy in U.S. history, involving $107 billion in assets. To generate real profit, he'll have to consider unloading its shrinking paging business and handing out even more pink slips. He also wants to turn the company into...

Author: /time Magazine | Title: WorldCom: Showing Signs of Life | 12/30/2002 | See Source »

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