Word: host
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Dates: during 1970-1979
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...Council meeting this week in Panama City. The meeting almost certainly will be used to air a variety of Latin American grievances, such as Argentina's demand for the Falkland Islands and Guatemala's demand for British Honduras. But the noisiest grievances will presumably come from the host. Panamanian Strongman Omar Torrijos calls the Canal Zone "a tumor that must go through the operating room...
...that the body is constantly producing abnormal cells. "Let's think of control of cancer rather than cure," says Old. "Cancer is not a killing disease; what kills is progressive cancer. What we're trying to do is not eliminate cancer but establish an equilibrium between cancer and its host...
...Doctors had experimented with bone-marrow transplants in the mid-'50s, primarily to combat leukemia. But their efforts proved generally unsuccessful. Immunologically sound bone marrow contained cells that recognized the recipient of this gift as "foreign." The new cells, in a phenomenon known as "graft v. host" reaction, thus rejected the host, producing lymphocytes capable of reacting with and destroying his tissue. In fact, the reaction, combined with infection and other factors, could prove fatal to the recipient whose immune system was either weak or absent...
...suffering from hereditary immunodeficiency disease, which had already killed twelve infants on the maternal side of his family. Thinking back to work that he himself had done in 1956, Good remembered that mice given bone marrow from donors whose cells were genetically similar suffered from graft-v.-host reaction but never died from it. He reasoned that David, too, would survive if a good tissue match could be found...
...team inserted a needle into the bone of the sister's leg and withdrew about a billion marrow cells. Then, they injected the cells into David's peritoneal cavity, relying on the cells' natural homing instincts to guide them to the bone marrow. The graft took. Graft-v.-host reaction set in, peaked and finally passed. The new cells overcame David's lethal legacy by giving him the immune system he lacked; the child, now five, is immunologically normal...