Word: houck
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PHILIP A. HOUCK Fairfield, Conn...
...more of today's knowledge about inflammation has been gained in the past ten years. Not until a fortnight ago did the International Inflammation Club convene its first symposium. The club is an amorphous group with no officers or formal organization. Conceived by Biochemist John C. Houck of Children's Hospital in Washington, D.C., it drew together 80 researchers as guests of the Upjohn Co. at Brook Lodge in Michigan...
Total Mobilization. Some of them had interests so specialized that even other scientists could not understand their presentations. Houck had expected this. He had wanted the meeting to build bridges of communication between men who had never heard of one another's work, and that it did. And the scientists concurred on some basic aspects of the subject that will be important in the treatment of patients-some, admittedly, in the distant future, but others perhaps immediately...
Inflammation, all agreed, is one of nature's most basic defenses against injury. As such, Dr. Houck pointed out, it has to be enormously versatile because the injury may be a stabbing or abrasive wound, a burn, or invasion by infectious microbes. Even a sterile, uninfected wound summons inflammation to its aid. Since nature cannot construct individual defenses against an infinite variety of attacks from innumerable sources, said the Upjohn Co.'s Dr. E. Myles Glenn, it mobilizes everything at hand-the immune and clotting mechanisms, the blood-forming and lymph systems, the liver, and many others. Sometimes...
...Houck noted that three drugs, hydrocortisone, oxyphenbutazone (Tandearil) and indomethacin (Indocin), when injected into animals, all cause the release of an enzyme which is itself inflammatory-though all are prescribed as anti-inflammatory medicines in arthritis. This, he declared, is puzzling to the point of being "intellectually unpleasant." Dr. Arthur Bogden of Worcester, Mass., made the paradox still sharper. If hydrocortisone and aspirin are given to laboratory rats under certain conditions before they have arthritis, both have anti-inflammatory action. But after the rats have their arthritis, the hydrocortisone raises a certain enzyme level used as a measure of drug...