Word: huppert
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Dates: during 1961-1961
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...viruses cause some human cancers, as many medical researchers suspect, why is it that nobody can find the guilty particles in cancer cells? To this baffling question a brilliant French investigator offered an answer last week, and said he had found substantial proof for it. Dr. Joseph Huppert. 41, of the Institut Pasteur, gave his report to Manhattan's SIoan-Kettering Institute...
...Huppert began with the generally accepted fact that a normal cell contains chemically coded information-in ribonucleic acid (RNA) or deoxyribonucleic acid (DNA)-which determines how it reproduces itself. But, he suggested, ''a cell may acquire some wrong genetic information,' perhaps through the entry of a virus into the cell. The virus need not necessarily multiply within the cell; all that is necessary is for a piece of the virus' RNA or DNA to be substituted for part of the cell's normal nucleic acid...
...many, if not in most cases, this process will simply mean that the cell cannot reproduce because it cannot use the miscoded instructions. But in a few cases, said Dr. Huppert. it will incorporate the "foreign" information and reproduce abnormally, starting a cancer. The likelihood of this is increased when an other, non-cancer-causing virus happens to be present. Dr. Huppert said he and his colleagues have induced tumors in animals with the nucleic-acid "core'' of a virus found in a human tumor...