Word: hwang
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Just weeks after Korean authorities confirmed that stem cell research from the laboratory of Woo Suk Hwang had been fabricated, the medical community is reeling from another scientific scandal. The editors of the New England Journal of Medicine announced this evening that they have doubts about the research of Norwegian cancer expert Dr. Jon Sudbo of the Radium Hospital in Oslo. Their formal ?Expression of Concern? about two articles they published from Sudbo and his colleagues in 2001 and 2004 is being released at the Journal?s website (content.nejm.org). This comes after the Lancet issued its own ?Expression of Concern...
With an investigative panel from Seoul National University (SNU) scheduled to deliver its final report this week on Dr. Hwang Woo Suk's already largely discredited stem-cell research, the South Korean scientist's career seems all but finished...
...Hwang's claims create such excitement? In a 2004 paper, Hwang reported that his team was the first to clone human embryos and extract lines of embryonic stem cells (ESCs) from them, harvesting a single line of ESCs from experiments involving 248 human eggs. ESCs can potentially grow into any type of body tissue, and lines created through cloning might one day help treat conditions like Alzheimer's or diabetes without the risk of immune rejection. In 2005, Hwang claimed to improve his process, using an average of 17 eggs to create an ESC line...
...what went wrong? SNU says that Hwang used far more eggs than he had admitted. Egg donation carries a small risk of serious side effects. Hwang's technique would likely never become a viable treatment if each ESC line required hundreds of eggs to produce...
...mother as part of the egg's genetic contribution. Identical twins, for example, have the same nuclear and mitochondrial DNA, since they're produced when a single egg is fertilized and the resulting embryo splits in two. With a clone, the situation is different. Because the cloning process that Hwang says he used to create Snuppy involves two dogs--one for the nucleus and another for the egg--Snuppy's mitochondrial DNA should not match Tai's. That's what Rhee's scientists say they've found and what Hwang undoubtedly hopes the university and Nature will find as well...