Word: hwang
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...Hwang Woo-Suk, the Korean scientist who gained international media attention for making fraudulent claims about cloning a human embryo, may have inadvertently made a significant breakthrough in stem cell research, a team of scientists led by a Harvard professor announced last week...
George Q. Daley, an associate professor at Harvard Medical school and a member of the Harvard Stem Cell Institute (HSCI) Faculty Executive Committee, led the team that studied Hwang’s research. They determined that Hwang produced human stem cells through parthenogenesis, a process whereby an unfertilized egg begins to divide through external stimulation...
...Hwang know what he had accomplished and purposefully suppress that knowledge? Or did he stumble into the parthenogenetic breakthrough by accident, oblivious to the biological milestone? While Hwang has not commented on his work apart from apologizing for his actions in 2006, most experts believe that he and his team were unaware of their achievement...
...donor's cell, usually a skin cell, into an egg cell, whose DNA-containing nucleus has been removed. The new cell then starts to divide and produce stem cells. In some cases, however, through mistakes in the nuclear-transfer process, eggs may begin dividing on their own. And Hwang may have increased his chances of parthenogenesis by using the gentler, squeezing technique he pioneered to remove the egg's nucleus; the process may have actually left behind enough genetic material for the egg to spontaneously divide. "As the egg starts to mature, [these elements] migrate and after about an hour...
...find out whether Hwang's stem cells came from a single egg, Daley's team, which included leading researchers from England, Japan and Canada, conducted a whole-genome analysis of the DNA from Hwang's stem cell line. By analyzing tens of thousands of gene snippets on the cells' genomes, and comparing these signatures to those of the egg donor and of the skin cell donor, they were able to determine that the DNA fingerprint of the stem cells was consistent with that of the egg. "The genetic signature of a parthenote is very very obvious," says Daley. Because...