Word: hypoplasia
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...sparse and very fine (i.e., small diameter). It is brittle and never grows long enough for an Amish mother to braid a dwarf daughter's locks. Since the main features of this form of dwarfism are underdevelopment of cartilage and hair, Dr. McKusick has named it "cartilage-hair hypoplasia," or CHH. Only two similar cases have now been found among non-Amish in France and two more in Minnesota...
Manhattan Obstetrician Raphael Kurzrok believes that a large number of miscarriages are caused by "genital hypoplasia" (malformation plus deficient hormone activity). His analysis: in some women, because of insufficient output of estrogen (a female hormone) during pregnancy, expansion of the uterus fails to keep pace with growth of the fetus. Rupture of the membrane and miscarriage result...
...genital hypoplasia sufferers who desperately want to become mothers, Dr. Kurzrok holds out new hope: hormone therapy. In the current New York State Journal of Medicine he reports on the treatment of 42 women with previous histories of repeated miscarriages. After a daily dose of estrogen throughout the months of pregnancy, 39 gave birth to normal children; two had miscarriages for other reasons than genital hypoplasia, one for an undetermined cause...
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