Word: ibuprofen
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...side effects, two studies last week showed that both antacids and H2 blockers may mask symptoms of bleeding ulcers among people with rheumatoid arthritis. These patients often take the pills thinking they will relieve bleeding that can occur with high doses of rheumatoid-arthritis drugs like ibuprofen. While neither H2 antagonists nor antacids cause bleeding, they may keep those with ulcers from recognizing the need to seek help. H2 blockers still have fewer side effects than antacids. (Tagamet may interfere with the body's ability to metabolize certain drugs, but the incidence, say researchers, is not significant.) Meanwhile, calcium-based...
Less than a decade ago, aspirin seemed to be losing some of its luster. Marketed since the beginning of the century as a uniquely effective pain and fever fighter, it was suddenly forced to compete with two major rivals -- acetaminophen (Tylenol, Anacin-3) and ibuprofen (Advil, Nuprin) -- that had many of aspirin's benefits without some of its side effects. Worse, aspirin had been linked to Reye's syndrome, a rare but sometimes deadly condition that can afflict children after a bout of flu or chickenpox. Doctors immediately ceased to recommend it for most youngsters, and liquid Tylenol replaced orange...
...wonder drug has made a wondrous comeback. In recent years it has been shown to be a powerful inhibitor of heart attacks and strokes -- a virtue neither acetaminophen nor ibuprofen can match. And last week came preliminary evidence of another major benefit: aspirin reduces the risk of death from colon cancer, a disease that kills 50,000 Americans a year. A major study by the American Cancer Society, reported in the New England Journal of Medicine, found that people who took 16 aspirin tablets or more each month (or equivalent doses of related but lesser known anti-inflammatory drugs...
...properties. Unlike acetaminophen, which acts only on the central nervous system, aspirin (chemical name: acetylsalicylic acid) has an extraordinarily broad range of effects. The reason is that it interferes with the production of a diverse class of substances known as prostaglandins, which are found in nearly every body tissue. (Ibuprofen does too, but in a much more limited...
Healthy people who occasionally take ibuprofen should not be concerned. But the scientists believe that anyone who is 80 or older or who has severe heart disease or other conditions that reduce blood flow to the kidneys should consult a doctor before taking large doses -- six to twelve tablets a day -- for periods of a week or more...