Word: imitrex
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...Pain study, which was led by Italian neuroscientist Martina Amanzio, reviewed 73 clinical trials conducted between 1988 and 2007. All the previously published trials pitted potential antimigraine medications against sugar pills. The medications included nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen (Advil); triptans, which include Imitrex; and anticonvulsant drugs like Topamax. Those three categories of drugs carry different adverse effects: NSAIDs, for instance, often cause stomach problems; anticonvulsants can cause paresthesia (tingling) and memory impairment. Interestingly, patients who took sugar pills tended to report nocebo problems consistent with whatever drug they thought they might have swallowed...
...brain, causing them to constrict. The body then overreacts, sending serotonin levels plummeting and forcing the blood vessels to expand to several times their normal size. This cycle of contraction and expansion results in the headache's characteristic throbbing pain. In 1993 Glaxo introduced a drug called Imitrex that allowed doctors for the first time to prescribe something that was specifically designed to interrupt the cycle of pain. Last week Glaxo announced encouraging results for its second-generation migraine medication, a new drug called Amerge that lasts longer than Imitrex and is less likely to trigger unpleasant side effects...
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