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...effective, a weight-loss drug must counteract some of the body's most basic biological mechanisms. Evidence suggests that weight is controlled in much the same way that a thermostat regulates room temperature. According to this explanation, known as the set-point theory, the brain plays an importatnt role in determining a person's ideal weight, which remains more or less constant throughout adult life. Whenever a person loses weight, a portion of the brain called the hypothalamus responds by increasing the appetite and slowing the metabolism so that the body can store more fat. By contrast, when a person...

Author: /time Magazine | Title: Desperately Seeking a Flab-Fighting Formula | 1/16/1995 | See Source »

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