Word: imprinted
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...with four home runs in four games this weekend, the sophomore infielder put his stamp on more than just the ball club. He left an imprint on Harvard baseball history...
...answer, most scientists suspect, has to do with a peculiar process called parental or genomic imprinting, which seems to occur only in mammals. Biologists have discovered subtle changes that are made to about 100 genes and that make a mammalian DNA molecule distinctly male or female. How does a cell know which form to imprint on its DNA? It checks out the surrounding microscopic environment to see if it seems more male-like or female-like...
...other things being equal, an embryo must have both a maternal genomic imprint (usually from an egg) and a paternal genomic imprint (usually from a sperm), or it won't grow properly. If it has two paternal imprints, the placenta grows but not the embryo. If it has two maternal imprints, the embryo grows but not the supporting placenta. Defects in imprinting in humans are thought to contribute to such neurodevelopmental ailments as Prader-Willi syndrome and perhaps some forms of autism. Genes that have lost their imprinting have also shown up in brain tumors...
What a team of researchers led by Tomohiro Kono at the Tokyo University of Agriculture did was create a genetically modified strain of mice in which the females produce eggs with an imprint that is somewhat father-like. Then, in a key step, the team extracted immature eggs from the newborn mice of this strain. Why is this important? The immature eggs had the most paternal imprint of all because they had not yet had time to sense that they were living in a female. By fusing these father-like eggs with normal, mother eggs, the Japanese researchers were able...
...golf course." These include matters of etiquette--How many practice swings can I take?--that can intimidate new players. Alexander says the course owners, not the golf pros, must run the reforms. Ron Drapeau, CEO of Callaway Golf, the $814 million Big Bertha manufacturer that will imprint playgolfamerica.com on its advertising, says any strategy is better than none at all: "It can't be put on one group's shoulders. Look, we're going down some blind alleys, and we're going to make mistakes. But I'm excited, because for the first time in golf's history...