Word: indinavir
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...said that analysis found that mutations at solely sites 46 or 82 lead to weak resistance to Indinavir, an HIV protease inhibitor, but mutations at site 54 alone have no effect. More surprisingly, mutations at sites 54 and 45 actually made the virus even more susceptible to the drug...
...Eisenberg stressed the need for traditional medical doctors to be willing to talk with patients about the herbal or botanical substances they are taking. He cited, for example, evidence that the popular herbal supplement St. John's Wort seriously impaired the ability of Indinavir, an anti-viral drug used to treat AIDS, to function in the blood stream...
WORT-LESS Here's a downer about the wildly popular herbal antidepressant Saint-John's-wort. However potent its many fans may believe the pretty yellow flower's extract to be, it interacts dangerously with two medications: the antirejection drug cyclosporine, used in organ transplants, and the protease inhibitor indinavir, used to treat AIDS. In both cases, Saint-John's-wort reduced blood concentrations of the drug, rendering it less effective...
Some individual cases are so desperate that the pharmaceutical companies have decided to help out. Last summer New Jersey-based Merck announced that it would make its protease inhibitor, indinavir, available free to 4,100 people who couldn't otherwise afford it. Other firms have pledged to continue treatment for those patients who participated in their clinical trials...
Both ritonavir and indinavir belong to a promising new class of drugs called protease inhibitors, which block production of a key enzyme, protease, that the virus needs to replicate itself. It was only last December that the U.S. Food and Drug Administration approved the first protease inhibitor, Hoffmann-La Roche's saquinavir. Ritonavir and indinavir could get the FDA go-ahead--and reach doctor's offices--as early as this summer. "The data are as good as anything I've seen," says Dr. Anthony Fauci, a leading AIDS expert at the National Institutes of Health...