Word: indinavir
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Dates: during 1996-1996
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Some individual cases are so desperate that the pharmaceutical companies have decided to help out. Last summer New Jersey-based Merck announced that it would make its protease inhibitor, indinavir, available free to 4,100 people who couldn't otherwise afford it. Other firms have pledged to continue treatment for those patients who participated in their clinical trials...
...report from Merck that a second drug, indinavir, used in combination with two other drugs, AZT and 3TC, reduced the levels of HIV in the blood of 24 patients an unprecedented 1,000 times...
Both ritonavir and indinavir belong to a promising new class of drugs called protease inhibitors, which block production of a key enzyme, protease, that the virus needs to replicate itself. It was only last December that the U.S. Food and Drug Administration approved the first protease inhibitor, Hoffmann-La Roche's saquinavir. Ritonavir and indinavir could get the FDA go-ahead--and reach doctor's offices--as early as this summer. "The data are as good as anything I've seen," says Dr. Anthony Fauci, a leading AIDS expert at the National Institutes of Health...