Word: indocin
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...than $100 million in 1987 sales, well ahead of Britain's Glaxo Holdings, which has five products in that rarefied range. Among Merck's best sellers are Vasotec, a blood pressure-lowering drug; the antibiotics Primaxin and Noroxin; Pepcid, used to treat peptic ulcers; the anti-inflammatories Clinoril and Indocin; an antiglaucoma agent named Timoptic; and the hepatitis fighter Recombivax HB, the first genetically engineered vaccine licensed for human...
...chairs the House Health and Environment Subcommittee: "Merck, like other big drug companies, has been raising prices dramatically and has introduced new drugs at shockingly high prices." Even drugs whose patents have long expired remain expensive. A bottle of 60 25-mg tablets of Merck's arthritis- fighting Indocin sells in New York City for $28, vs. $12 for an equivalent generic brand...
Fish is presently trying out an antiinflamatory drug called indocin, and if it works, he will be back in action within the next four days. But it may be weeks before he can reclaim a spot in the starting line...
...Houck noted that three drugs, hydrocortisone, oxyphenbutazone (Tandearil) and indomethacin (Indocin), when injected into animals, all cause the release of an enzyme which is itself inflammatory-though all are prescribed as anti-inflammatory medicines in arthritis. This, he declared, is puzzling to the point of being "intellectually unpleasant." Dr. Arthur Bogden of Worcester, Mass., made the paradox still sharper. If hydrocortisone and aspirin are given to laboratory rats under certain conditions before they have arthritis, both have anti-inflammatory action. But after the rats have their arthritis, the hydrocortisone raises a certain enzyme level used as a measure of drug...
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