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Jacobs-Lorena and his colleagues at Johns Hopkins University have taken a different approach to combating malaria. They have engineered a mosquito that produces an extra protein in its gut, which blocks the malarial parasite from infecting it. The team recently discovered unexpectedly that one of their engineered mosquito strains is “fitter” than ordinary mosquitoes. Once you infect it with a certain strain of mouse-borne malaria parasite, it lives longer and produces more offspring than infected wild-type mosquitoes. Place equal numbers of the two types of mosquitoes into the same cage...

Author: By Matthew S. Meisel | Title: Shooting The Magic Bullet | 3/22/2007 | See Source »

...reality, the technology isn’t nearly ready to take flight. The mosquito species that Jacobs-Lorena used is not the most harmful of mosquito species and the parasite used does not infect humans. Furthermore, the modified mosquitoes only have an evolutionary advantage over infected mosquitoes, and in the wild only a small fraction of mosquitoes are infected with malaria...

Author: By Matthew S. Meisel | Title: Shooting The Magic Bullet | 3/22/2007 | See Source »

...Currently available ARVs work at both the beginning and the end of the HIV life cycle; the most recently approved class in 2003, called fusion inhibitors, start early, working to block HIV's attempt to bind and infect healthy cells to begin with. Next come the two oldest classes of drugs, which prevent the virus from transforming its genetic material from RNA to DNA. And finally, jumping to the very end of HIV's mission, the protease inhibitor drugs keep the virus from making its final protein coat, which it needs to re-emerge from the infected cell in order...

Author: /time Magazine | Title: Beefing Up the Arsenal Against AIDS | 3/2/2007 | See Source »

...renowned pianists such as Vladimir Ashkenazy? Gramophone editor James Inverne says that there can be hundreds of world-class recordings of a given piece, and no critic can be familiar with identifying nuances of all its interpretations. And perhaps, more importantly, classical connoisseurs simply didn't expect plagiarism to infect their art form. "The art and literary worlds are often hit by accusations of copying," Inverne says. "We've never experienced a scandal like this before...

Author: /time Magazine | Title: Of Concertos and Copyrights | 2/22/2007 | See Source »

Once again, gay activists who claim to speak for us have gone too far. Every time they let the culture of victimhood infect and pervade their worldview, they lose a little credibility. When the real fights come along, when latter day Anita Bryants seek to impose real harm on gay men and women, gay rights activists will be impotent to act. No one will trust them, or care to listen to what they have...

Author: By Ari E. Waldman | Title: Gay? Grab a Snickers | 2/15/2007 | See Source »

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