Word: inhibitive
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Dates: during 2000-2009
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...Best of all, the enzyme-deprived mice were in robust health, producing baby mice with no problem and generally acting like any other mouse. That's great news for obesity researchers, who speculate that scientists may figure out a way to inhibit the fat-metabolizing enzyme in humans and control weight gain. And such a pill would be nothing short of a miracle for many struggling to shed dangerous excess pounds...
TEATIME No wonder researchers had great hopes for green tea. It's loaded with powerful anticancer agents like polyphenols, which, in the lab at least, inhibit cell proliferation. Well, time to reread those tea leaves. A study shows that folks who drink five or more cups of green tea a day are just as likely to develop stomach cancer as those who barely take a sip. Don't toss out the teapot, however. Green tea may still protect against other cancers...
...Harvard University neurologist Dr. Kenneth Kosik emphasizes, precious few new drugs prove to be anything close to magic bullets. Indeed, Kosik, along with many others, thinks it is quite likely that controlling Alzheimer's disease will require more than one type of drug. In addition to compounds that inhibit plaques, for example, patients may need drugs that prevent the formation of tangles that disrupt nerve cells from within...
...most famous of these are Wyeth-Ayerst's Enbrel, and Remicade, made by a subsidiary of Johnson & Johnson, which have been in use for roughly two years. Both inhibit a messenger in the inflammatory cascade known as the tumor necrosis factor (TNF). The drugs are more effective than traditional medications, and more likely to retard joint degradation. "The idea that biologics could prove effective against autoimmune disease has been firmly established by the TNF story," says Dr. H. Michael Belmont of the Hospital for Joint Diseases in New York City...
Thanks to technologies spawned by genomics, the list of potential drug targets is growing rapidly. Human Genome Sciences and Seattle-based ZymoGenetics, for instance, are independently developing drugs to inhibit a newly discovered factor that stimulates B cells and is produced copiously in RA and lupus patients...