Word: inhibitive
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...academic realm. Rarely were we encouraged as students to ponder methods of inquiry in depth at an early stage in the learning process. Only on a cursory level was investigation and imagination fostered--there was always rote memorization, an atmosphere of discipline and a strictly structured day to inhibit free thought...
Grapes are "packed with flavonoids which are phytochemicals and, in particular, resveratrol, which has been shown in laboratory tests on animals to inhibit tumor growth at three different stages," said Peracchi-Douglas...
...chromosomes--site of the cell's genes--begin to fray, rather like shoelaces that have lost their plastic tips. Eventually, such aged cells die--unless, like "immortal" cancer cells, they produce telomerase, an enzyme that protects and even rebuilds telomeres. Scientists have long dreamed of drugs that would inhibit the immortalizing enzyme because, observes M.I.T. biochemist Robert Weinberg, "then maybe cancer cells would run out of telomeres and just poop...
...protein, it turns out, bears an intriguing resemblance to an enzyme produced by HIV, the retrovirus that causes AIDS. Indeed, the AIDS drug AZT has already been shown to inhibit telomerase activity. But the viral enzyme and the human enzyme, says Colorado's Cech, are only 20% identical, which explains why AZT is not an ideal telomerase inhibitor. "What we want," he declares, "is a compound that fits telomerase the way a hand fits a glove...
...odds that such a compound will materialize now seem high. But experts caution that it could take years before the first telomerase inhibitors are ready to be tested on humans to determine if they'll have any serious side effects--or if they'll actually inhibit tumor growth. Such questions are perhaps one reason Geron's stock leveled off at week's end, closing at 12 1/4 a share...