Word: inhibitors
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WORT-LESS Here's a downer about the wildly popular herbal antidepressant Saint-John's-wort. However potent its many fans may believe the pretty yellow flower's extract to be, it interacts dangerously with two medications: the antirejection drug cyclosporine, used in organ transplants, and the protease inhibitor indinavir, used to treat AIDS. In both cases, Saint-John's-wort reduced blood concentrations of the drug, rendering it less effective...
...Soon ACE inhibitors, a widely used high-blood-pressure medication, may be added to the roster of pills taken by folks at risk for a heart attack. A major study, released ahead of schedule to get out the good word, shows that daily doses of the ACE inhibitor ramipril led to a dramatic 25% decline in heart attacks and strokes among diabetics and patients with a history of heart disease. Cost: 85[cents...
...first, scientists could not develop angiogenesis inhibitor drugs because there was no established test for the drugs' effects on the growth of blood vessels...
Three years after his initial discovery, in 1975, Folkman and colleague Henry Brem discovered the first angiogenesis inhibitor molecule in cartilage. Researchers, including Folkman, had to learn to culture blood vessels and try to test angiogenesis inhibiting compounds...
...Ingber himself who, as a post-doctoral fellow, discovered the drug TNP-470, the first angiogenesis inhibitor from Folkman's lab to enter human clinical trials...