Word: inhibitors
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...years ago, King began to design an inhibitor to prevent this form of PKC from constricting blood flow and causing vessel leakage in the retina...
Along with fellow researchers Dr. Lloyd P. Aiello, assistant professor of ophthalmology at HMS and the Joslin Diabetes Center, and Dr. Szen Bursell, assistant professor of ophthalmology at HMS, the inhibitor, now known as LY333531, was created...
When tested on diabetic animals, the researchers found the inhibitor to be effective and non-toxic. These results were successful enough to warrant an initial ophthalmologic clinical trial, the results of which were first announced at last month's symposium honoring the 100th birthday of the Joslin Diabetes Center...
Malkin is quick to point out that one growth-factor inhibitor isn't going to cure cancer. Cancer is a complicated disease. Tumors usually are made up of different types of cells, expressing different genes, sensitive to different growth factors and therefore responding to different drugs. "When you are trying to kill cancer cells, you're always likely to need combination treatment," says Merck's Scolnick. Like AIDS treatments, the new generation of cancer drugs will need to be combined with older drugs and possibly with one another to be most effective...
PLAY ALL DAY Monsanto's Celebra is a new-generation anti-inflammatory drug called a COX-2 (cyclo-oxygenase) inhibitor. It blocks arthritis pain without attacking the stomach lining, a major problem with anti-inflammatories. To be co-marketed by Pfizer in the U.S., Celebra could go on sale...