Word: inhibitors
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Dzau's current strategy is to use gene therapy to insert a cell-division inhibitor into the vein cells. This could prevent the veins from overgrowing thereby protecting the patients...
About 10 years ago, the first inhibitor was discovered. Clinical trials began in 1992 to establish the use of the inhibitor--TNP-470--as a cancer drug, largely as an adjunct after chemotherapy...
...well known that some tumors suppress the growth of metastases," Folkman said. "Our question was [that] if tumor size is ultimately controlled by endothelial proliferation, could a primary tumor suppress growth of a distant metastasis by delivering an endothelial inhibitor to it through the circulation...
Such delays can prove fatal. Tanya (not her real name), an 11-year-old from Miami who is HIV positive, had to watch her younger sister die last year while they waited for permission to take a protease inhibitor. Both girls had been infected in utero; their mother died a couple of years later. "The [pharmaceutical company] said they didn't have the right dosage for children," the girls' foster mother recalls. "They told us to hold out. But by the time she got accepted, it was too late [for Tanya's sister]." In February, Tanya started combination therapy with...
...just because they can get protease inhibitors into their youngest patients doesn't mean that pediatricians are eager to do so. With children as with adults, patients' first response to a protease inhibitor is often their best. If they take the drug too soon, the HIV in their body can become resistant not only to that particular drug but to the whole family of protease inhibitors. As a result, most doctors will give the drugs only to those children who are clearly deteriorating...