Word: inhibitors
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Dates: during 1941-1941
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...animals. They also found an activator in the blood plasma which enabled renin to work. The combination of renin and this activator was dubbed angiotonin. As a working hypothesis, angiotonin was marked as the chemical cause of high pressure. Further experiments showed that normal kidneys probably manufacture an "inhibitor" substance, which destroys or neutralizes surplus angiotonin, keeps the pressure within normal bounds. Two research teams, including Dr. Page's in Indianapolis, recovered from kidney extract inhibitors which lowered the pressure of animals 50 to 100 points...
Then, at last, it was time to see whether the inhibitors would give relief to hypertensive humans. For the past year 17 lucky patients of Dr. Page's have been getting inhibitor injections. In general, their pressures have been lowered and kept down, their headaches, chest pains and shortness of breath have disappeared, "their feeling of well-being is evident." Hypertensives with impaired vision due to blood congestion in the eyes have been greatly improved...