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...Tepper's team used this reasoning to try to improve on the popular blood-pressure-lowering drugs known as ACE inhibitors. These compounds inhibit an enzyme called angiotensin-converting enzyme (ACE), which is responsible for making the muscle cells in blood vessels contract, which drives blood pressure up. By interfering with the activity of this enzyme, ace inhibitors keep blood vessels relaxed and pressure down...

Author: /time Magazine | Title: Brave New Pharmacy | 1/15/2001 | See Source »

...Harvard University neurologist Dr. Kenneth Kosik emphasizes, precious few new drugs prove to be anything close to magic bullets. Indeed, Kosik, along with many others, thinks it is quite likely that controlling Alzheimer's disease will require more than one type of drug. In addition to compounds that inhibit plaques, for example, patients may need drugs that prevent the formation of tangles that disrupt nerve cells from within...

Author: /time Magazine | Title: The Hunt For Cures: Alzheimer's Disease | 1/15/2001 | See Source »

...most famous of these are Wyeth-Ayerst's Enbrel, and Remicade, made by a subsidiary of Johnson & Johnson, which have been in use for roughly two years. Both inhibit a messenger in the inflammatory cascade known as the tumor necrosis factor (TNF). The drugs are more effective than traditional medications, and more likely to retard joint degradation. "The idea that biologics could prove effective against autoimmune disease has been firmly established by the TNF story," says Dr. H. Michael Belmont of the Hospital for Joint Diseases in New York City...

Author: /time Magazine | Title: The Hunt For Cures: Autoimmune Diseases | 1/15/2001 | See Source »

Thanks to technologies spawned by genomics, the list of potential drug targets is growing rapidly. Human Genome Sciences and Seattle-based ZymoGenetics, for instance, are independently developing drugs to inhibit a newly discovered factor that stimulates B cells and is produced copiously in RA and lupus patients...

Author: /time Magazine | Title: The Hunt For Cures: Autoimmune Diseases | 1/15/2001 | See Source »

...they relay this information quickly to Washington and military planners? The embassy could ill afford to make inherently subjective security decisions on its own, without senior consultation; while providing a unique, direct perspective on Yemen-specific security issues, their closeness to the host country could actually inhibit objective analysis. On the other hand, if Washington were informed and no move to enhance security measures ensued, then a review of the communication between the embassy, the military and the intelligence community is essential...

Author: By John D. Moore, | Title: Lives and Truth at Stake | 1/5/2001 | See Source »

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