Word: insulin
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...long as 2½ years, hundreds of thousands of diabetics all over the world have been treated with tablets of tolbutamide instead of insulin injections. Many have rejoiced at their new-found freedom from the need for daily needlework. Last week the Upjohn Co. (which markets the drug as Orinase) decided to lay on the line just what it will and will not do. To its Kalamazoo headquarters Upjohn invited 500 physicians to hear reports from Germany's Dr. Ernst Pfeiffer, one of the first investigators to use the drug, and from Chicago's Dr. Rachmiel Levine...
...patients treated since the late summer of 1955 at Frankfurt's University Medical Clinic, said Dr. Pfeiffer, 78% achieved good control of their diabetes, and the benefit shows every sign of lasting. (Tolbutamide is not a substitute for the body's natural insulin. It apparently achieves its effect by boosting the release into the blood stream of insulin, which, in most adult patients, continues to be secreted by the pancreas.) Tolbutamide did no good from the start in 8% of cases. In a further 8% it had to be dropped because early good results wore...
Died. Dr. Manfred Joshua Sakel, 57, Austrian-born U.S. psychiatrist, originator of insulin shock treatment for schizophrenia; of a heart attack; in Manhattan. In 1927, while treating a famed European actress who was a diabetic and drug addict, Dr. Sakel accidentally administered an overdose of insulin, was amazed to see her craving for morphine subside. Theorizing on the correlation between physical and mental illnesses, he went on to try his overdoses on alcoholics and schizophrenics; in both cases the patients improved...
...five men, 21 women) was dosed with chlorpromazine, which increased the sedative effect of barbiturates. By the end of the first week they were sleeping 20 to 22 hours a day. After getting solid food during this week, they were switched to semisolid. They got five units of insulin half an hour before each meal. With the onset of deep sleep, patients were wakened three times a day for meals and toileting. By the tenth day they were put on intensive electroshock treatment-usually one treatment daily, and often receiving four or five shocks in two to three minutes...
...heroine (Anna Kashfi) never finds herself in anything more exciting than the hero's alms. He sends her candy bars too. By the time the lights finally go up, the sugar count of this picture is so dangerously high that theater managers might be well advised to offer insulin shots in the lobby...