Word: interleukins
(lookup in dictionary)
(lookup stats)
Dates: all
Sort By: most recent first
(reverse)
...focused on one such protein, called tumor necrosis factor. Immunex's treatment, which worked so effectively for Lindagail Dixon, consists of genetically engineered proteins that sop up excess tnf, interrupting the cycle of destruction. A third tactic, being developed by Amgen of Thousand Oaks, California, targets another inflammatory protein, interleukin-1, in much the same way. If approved by the FDA, all three drugs could be on the market in a couple of years...
...caused by the immune system's running amuck and attacking the body's connective tissue. Their strategy was to expose cells in the swollen tissue lining their patient's finger joints to genetically engineered viruses. These viruses carried a gene responsible for a protein that blocks the action of interleukin-1, a substance that stimulates immune-system activity. Without that stimulation, the doctors hope, the immune system will halt its assault on the joint linings...
...Scientists have the best evidence yet that immunotherapy- using the body's immune system to fight disease -- is an effective way to treat certain cancers. After giving the genetically engineered drug Interleukin 2 in high doses to 283 patients with spreading kidney or skin cancer, researchers found that a significant number stayed in remission for periods from seven to 91 months...
...plastic bubble that protected him from the outside world. Now, nearly 10 years after David's death, doctors have isolated the faulty gene responsible for his rare condition. In an article in Cell, researchers report that the mutation causes immune cells to produce defective copies of a receptor for interleukin-2, one of the most important molecular regulators of the body's defense system. Eventually scientists hope to transplant normal copies of the gene into the blood cells of affected children, thereby curing them. The research might also lead to new strategies for restoring the damaged immune system of people...
...from the National Institutes of Health and the Food and Drug Administration to treat 15 people with TNF-gene- altered cells, including patients with advanced kidney or colon cancer. Another 15 individuals with the same diseases may receive injections of tumor cells that have been genetically altered to produce interleukin-2 -- a protein that stimulates tumor-fighting lymphocytes -- instead of TNF. All the patients have failed to respond to standard therapy...