Word: iproniazid
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...legion of the emotionally depressed had high hopes when iproniazid was found 18 months ago to be an effective treatment in many cases. But the hopes were dashed when it was reported that the drug caused too many dangerous side effects, notably liver damage (TIME, April 21). Since then, instead of being prescribed indiscriminately for office patients, iproniazid is being used so carefully that it appears to be no more dangerous than many another potent drug. It is used not only in psychiatry, but also for cancer patients when they know the end is near, and in some unrelated disorders...
...Catron, made by Milwaukee's Lakeside Laboratories, Inc. (still known in many hospitals as JB-516), works faster than iproniazid in smaller doses, and appears effective in the liard to treat depression of children and adolescents...
...Trouble for iproniazid, the remarkable new anti-depression drug introduced last year (TIME, Dec. 16), was sparked last week by the death of a San Francisco woman whose physician prescribed it. A coroner's jury ruled that her death (of hepatitis) was directly due to the drug, which is trade-named Marsilid by its maker, Hoffman-La Roche Inc. of Nutley. N.J. In January and February the drug house cut the recommended daily dosage for moderately depressed patients from 150 milligrams to a maximum of 50. It tried to notify most practicing U.S. physicians, but the information never reached...
DRUG ADDICTION. Iproniazid (TIME, Dec. 16) has already proved valuable in some cases of drug addiction, by relieving the depression which led to use of narcotics; it may help similarly in cases of alcoholism associated with depression...
...since no one as yet has demonstrated a biochemical or physiological explanation." A side effect of psychic energizers is that most patients find that they need only four or five hours' sleep a night; some have gone this way for a year with no fatigue. Dr. Kline tried iproniazid himself, found he could do two days' work in one. A good question, he said, is "what the world would do with a daily increase of six or eight billion man-hours of time, which would result if two billion people saved three or four hours of sleep every...