Word: ipse
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HSCI co-director Douglas A. Melton and his colleagues have successfully created induced pluripotent stem (iPS) cells using a chemical that can replace two of the four potentially cancer-causing genes previously needed to reprogram adult cells into a mutable state. The findings, published Sunday on the Web site of...
Scientists have been exploring alternatives to the traditional—but harmful—retrovirus approach since researchers first reprogrammed human skin cells with the method late last year. Integrating these viruses into the cells' DNA causes permanent genetic manipulation, which can trigger malignant tumor growth, making them unsafe for...
Though he used money from the NIH New Innovator Award that he won last year, Hochedlinger’s research was not subject to federal embryonic stem cell restrictions because iPS cells are created from skin cells or blood cells instead of from embryos. His work was also funded in...
“As long as we don’t know that iPS cells are really as good as embryonic stem cells in generating all types of body tissues, we should be obliged to continue,” Stadtfeld said.
He noted that scientists are now able to generate iPS cells—which are embraced by those who oppose embryonic stem cell research—only because of previous work performed with embryonic stem cells.