Word: iressa
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...piece of information is that all the patients that we studied whose tumors shrank [from Iressa] have a mutation,” said Dr. Bruce E. Johnson ’75, an associate professor of medicine at Brigham and Women’s Hospital who co-authored the study...
...patient has a mutation in the human gene known as epidermal growth factor receptor (EGFR), Iressa has a much greater chance of slowing the growth of that patient’s tumor, the report said...
...patient tests positive for the EGFR mutation, then there is an 80-percent chance that Iressa will be effective, according to Johnson...
Johnson said the discovery of the linkage between the EGFR mutation and the drug effectiveness will reduce indiscriminate use of Iressa. “Before you decide to treat [a patient], you can sequence their tumor tissue for the appropriate mutation,” he said...
According to the report, there is hope that similar genetic identification techniques will allow drugs such as Iressa to be used on other types of cancer, including colorectal cancer...