Word: iressa
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When the lung cancer drug Iressa won approval from the Food and Drug Administration almost a year ago, it showed great promise as a tumor suppressor with side effects far less severe than those of chemotherapy...
...mystery of why Iressa, also called gefitinib, slowed tumor growth in only 10 percent of the patients who used it was solved only this month...
...team of researchers at the Dana-Farber Cancer Institute, which is affiliated with Harvard Medical School, found that a specific mutation in receptors in tumors cells is closely linked to the effectiveness of Iressa, according to the team’s report in yesterday’s online edition of Science magazine...
Enough To Make You Sick AstraZeneca's drug pipeline is looking dry. First its cholesterol drug failed clinical tests, then last week the lung-cancer drug Iressa, with forecast annual sales of $2 billion, followed suit...
...that's just the start. Gleevec, Tarceva and Iressa all break one of the most common signaling pathways by blocking an enzyme known as a tyrosine kinase. But the message that encourages a cancer cell to grow involves hundreds of biochemical signals that can travel by hundreds of different pathways. Each of those pathways represents a target, a link that could be interrupted with the properly designed drug...