Word: isoniazids
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...Medicine Theodore H. Cohen and Assistant Professor of Epidemiology Megan Murray will publish their findings in the May 2 issue of the Proceedings of the National Academy of Sciences. The new study puts an emphasis on areas with high HIV rates and warns against the effects of indiscriminately using isoniazid on all patients, Cohen said. Isoniazid preventive therapy, a drug treatment that reduces the rate at which latent TB becomes active, is increasingly being used to battle TB in areas with high rates of HIV. However, multi-drug resistant TB, defined as “resistant to isoniazid plus...
...Doctors now understand, after 40 years of using it, how one antituberculosis medication works: Isoniazid interferes with a protective coat around the TB bacillus. The discovery may lead to new medicines that could overcome drug-resistant forms...
...destroying the antibiotics and even molecular pumps that expel the drugs from the cell. The most recent example of bacterial resourcefulness came to light only two weeks ago. By deleting a single gene, an English-French research team announced, certain strains of the TB germ have protected themselves from isoniazid, currently the major weapon against this resurgent disease...
...last week's Nature, researchers from Hammersmith Hospital in London and from the Pasteur Institute in Paris report they have uncovered the genetic reason behind this dangerous trend. They have discovered that common forms of the TB bacterium bear a gene that makes it susceptible to the antibiotic isoniazid -- a gene that is missing in drug-resistant strains. The finding could lead to improved diagnostic tests that will help doctors treat people with drug-resistant TB before they can pass the infection on to others...
Thousands of TB patients sought out mountain air and were put on regimens of nutritious food. Chest X rays helped spot infected patches of lung. Finally, with the development of such drugs as streptomycin and isoniazid in the 1940s and 1950s, tuberculosis seemed on the way to being vanquished...