Word: isoniazids
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Dates: during 1960-1969
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...common drug reactions involves isoniazid, the most widely used drug against tuberculosis. One of the rarer reactions is found among victims of porphyria (see following story), who suffer acute attacks if they take barbiturates; they may also be sensitive to the sulfas. At the opposite end of the reaction scale, some victims of an unusual form of rickets need more than 1,000 times the normal quantity of vitamin D before they respond...
Even the most universally useful anti-TB drug, isoniazid, is harmless only if the patient's enzyme system can break it down readily: if not, he is likely to develop a generalized neuritis, or even an acute form of rheumatism...
...children would get the same medical and dental examinations as city youngsters. Now there are clinics for pregnant women and for well babies-along with proper care for the sick. Where TB patients once languished for lack of treatment in a sanatorium, health workers now give out supplies of isoniazid to be taken at home, and then they check to make sure the pills are really taken...
...indicated recent changes in the lungs-but again, nothing definite. This and other hints suggested that the anemia might be complicated by a tuberculous infection. So the doctors at once prescribed vigorous treatment with the most potent combination of anti-tuberculosis drugs: streptomycin, PAS (para-aminosalycylic acid) and isoniazid...
...Japan, tuberculosis researchers have developed a form of BCG vaccine that resists tropical heat. In a major test in Madras, WHO teams are treating TB victims with isoniazid (TIME, March 2, 1962) and are searching for another, equally inexpensive drug to combine with isoniazid to keep down resistant bacilli...