Word: isoniazids
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...indicated recent changes in the lungs-but again, nothing definite. This and other hints suggested that the anemia might be complicated by a tuberculous infection. So the doctors at once prescribed vigorous treatment with the most potent combination of anti-tuberculosis drugs: streptomycin, PAS (para-aminosalycylic acid) and isoniazid...
...Japan, tuberculosis researchers have developed a form of BCG vaccine that resists tropical heat. In a major test in Madras, WHO teams are treating TB victims with isoniazid (TIME, March 2, 1962) and are searching for another, equally inexpensive drug to combine with isoniazid to keep down resistant bacilli...
Stunned Bacilli. Isoniazid does not kill the tubercle bacilli or work a swift cure. What it does, explained Cornell University's Dr. Walsh McDermott, one of the first to test it, "is to incapacitate the bacilli so that they either die naturally or can be swept away by the body's natural defenses. A few may remain dormant, so we cannot say the patient is cured-only that his disease is arrested." But many patients can be treated at home from the start. "Others can be treated briefly, in a general hospital, and then go home. Bold surgery...
Patients must take the little white isoniazid pill three times a day with meals, for at least a year after their disease is arrested. Members of a TB victim's immediate family should also take isoniazid, especially youngsters with a positive tuberculin test reaction. The cost, never great, is now down to $1.50 per 100 pills for private patients; and health agencies, which distribute most of the pills free, can get them for as little...
Resistant Strains. One early fear about isoniazid has been justified: from 3% to 6% of new TB cases are caused by isoniazid-resistant bacilli. But the multiplication of these resistant strains can usually be checked by giving isoniazid with a second drug (streptomycin, para-aminosalicylic acid or cycloserine), and occasionally switching the combination...