Word: isoniazids
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Tuberculosis patients danced in the corridors of New York City's Sea View Hospital ten years ago to celebrate their speeding recovery on new drugs, mainly isoniazid, or INH (for isonicotinic acid hydrazide). Last week in Manhattan, the National Tuberculosis Association summed up the good that isoniazid has done in a decade-and surveyed what still must be done to keep TB on the run and eventually make it as rare as smallpox or typhoid...
...deaths in a population of 76 million), TB dropped by 1950 to seventh rank (34,000 deaths in a population of 151 million). Doctors still do not know all the reasons for this happy decline, but they do know what happened next. Isoniazid, first synthesized in Prague in 1912 and then forgotten, was rediscovered simultaneously by three groups of chemists (two in the U.S.). By 1960, despite the population boom, TB deaths dropped to 10,500. New TB cases reported fell from 86,000 in 1952 to 55,000 in 1960 (the decline is not as sharp as the drop...
When a mink gets TB, his veterinarian simply mixes some isoniazid with his daily horse meat. Last week the Public Health Service announced that isoniazid can be used to prevent tuberculosis in humans...
...Isoniazid is a pill made from two ingredients: a form of isonicotinic acid, plus hydrazine, a liquid that has also been used for rocket fuel. Isoniazid has been used by doctors since 1952 to arrest tuberculosis, and has helped cut the TB death rate in the U.S. from 30,000 a year to 10,000. Suspecting that it might also work for prevention, PHS four years ago began a test in Puerto Rico, Mexico and 16 states. Selecting 25,000 persons in daily contact with known tuberculars, researchers gave half of them daily doses of isoniazid; the other half...
...striking drop in TB mortality in the last few years (to about 12,000 in 1959) has been brought about by treatment with one or more of three wonder drugs: streptomycin (1944), para-amino-salicylic acid or PAS (1944) and isoniazid (1951). Eradication of the disease depends on full use of drugs, following aggressive case finding. There are now 400,000 known TB victims in the U.S. (150,000 with active disease), and an estimated additional 400,000 who have escaped detection...