Word: isoniazids
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...Isoniazid, wonder drug of 1952 against TB, may set off inflammation of the peripheral nerves, causing phantom sensations, numbness, burning pain and weakness. Unless caught early and treated with vitamin B6, this neuritis becomes permanent...
...dispute centers on Edwards' stubborn fight against Florida's "early-release" policy, which has cut the average TB patient's hospital stay from two years to around nine months by using such drugs as isoniazid and para-amino salicylic acid (bought with money Edwards wrung from the legislature). Edwards contends that the drug-treated patients will suffer relapses. When he heard talk this spring that the new policy might eventually allow the William T. Edwards Tuberculosis Hospital in Tallahassee (400 beds) to be converted into a mental hospital, he argued that if Florida disbands its TB facilities...
Experts agree that three combinations are justified: 1) streptomycin with other drugs (such as isoniazid) to discourage the appearance of resistant tubercle bacilli; 2) penicillin with streptomycin for inflammation of the heart lining (endocarditis); 3) tetracycline (or related antibiotics) with nystatin, not routinely but in some cases, to guard against secondary infection with the fungus monilia. Granting exceptions such as these, the Archives' editorialists conclude: "It is our firm conviction that the promotion and sale of such combinations should be discouraged...
Medical researchers reported last week that they have found a sort of untran-quilizer-a drug that shows promise in treating mental patients suffering from depression. It is no new chemical, but iproniazid (trade name: Marsilid), first cousin of isoniazid and a veteran of the 1951 campaign against tuberculosis. When it was given to TB patients at New York City's Sea View Hospital, they became happy, ate ravenously, gained weight and started dancing in the wards (TIME, March 3, 1952). Iproniazid was soon retired from widespread use because it produced undesirable side effects, such as dizziness, constipation, difficulty...
Arthritis Due to Infections. Once a major cause of arthritis, infections by common bacteria (notably gonorrhea and tuberculosis) no longer give the rheumatologists much concern. The joint symptoms, like the underlying disease, can be treated swiftly and effectively with such drugs as the sulfas, antibiotics and isoniazid. Can now be cured in nearly every case...