Word: isoniazids
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From Cook County Hospital, Dr. Daniel S. Kushner reported that a related germ, Mycobacterium fortuitum, can cause a disease like tuberculosis in mice. It is resistant to streptomycin and PAS (para-aminosalicylic acid) but it can be killed by isoniazid and also by the antibiotic tetracycline...
...Four tuberculosis researchers and two drug houses (Drs. Walsh McDermott Carl Muschenheim, Edward Robitzek and Irving Selikoff; Hoffman-La Roche Research Laboratories and Squibb Institute for Medical Research), for pioneering with isoniazid...
Knowing this, Drs. John Kurtzke and Louis Berlin jumped to no conclusions when a multiple sclerosis patient, treated with isoniazid for bed sores, began to speak so that they could again understand him. Instead, they tested isoniazid, the TB wonder drug, on 30 patients at the Veterans Administration Hospital in the Bronx. Three received no benefit, but 27 improved, and by a wider margin than previous M.S. patients who had been given other treatments. Most encouraging was the fact that four patients improved when they were given the drug and relapsed when it was stopped, then improved again when...
...disease has slid from first to ninth place among causes of U.S. deaths, and the rate has dropped to 16 per 100,000. There is a vaccine, BCG (Bacillus of Calmette and Guérin), which is fairly effective under some conditions. There are at least three wonder drugs-isoniazid, streptomycin & PAS-which can arrest a majority of TB infections, if not cure them. And with the aid of these drugs, daring surgery can save many patients...
Many Unknowns. Researchers reported many promising new things for the continuing fight against TB: a drug which is related to isoniazid, and looks just as good; a powdered extract of bacilli to make a vaccine which compares with BCG; better understanding of the need for vitamins A and C in treating patients. But the dominant tone of the meetings was a harshly realistic note sounded by the Rockefeller Institute's famed Bacteriologist Rene Jules Dubos...