Word: isotretinoin
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...pustules. (All together now: Eww.) That theory is unproved, but previous research on the effects of depression and acne drugs suggests the authors may be onto something: we know, for example, that antidepressants can improve acne. We also know that a widely used drug that treats acne, Accutane (isotretinoin), has been associated with an increase in depression, although no causal link has been established...
...Food and Drug Administration (FDA) last week tightened restrictions on the prescription acne medication Accutane (isotretinoin) and its generic equivalents. The drug has long been known to cause birth defects, and in 2002, Accutane's manufacturer, Roche, had put a program in place to further limit fetal exposure. But now the FDA says that program, along with several similar efforts to restrict use of the generic equivalents, created confusion and failed to protect pregnant women and their embryos. Under the new measures, manufacturers will register doctors who prescribe the drug, pharmacies that dispense it and patients who take it. Patients...
ACCUTANE This drug works wonders for severe acne when all else fails. Doctors have long known, however, that Accutane (generic name: isotretinoin) can cause birth defects in pregnant women. Indeed, the drug comes with a black-box warning, the strongest available to the FDA, to that effect. But each year several women still become pregnant while...
Last week brought the first modest success story in this new field of "chemo-prevention." Dr. Waun Ki Hong and colleagues from the University of Texas in Houston reported evidence that some cancers can be thwarted by isotretinoin, a man-made derivative of vitamin A that is sold as an anti-acne medication under the brand name Accutane. Fifty patients who had been successfully treated for cancer of the mouth and throat were given large daily doses of the drug for 12 months. After as much as three years, only two (4%) of the subjects developed a new cancer...
Doctors point out that isotretinoin is hardly a benign drug. In addition to causing side effects ranging from dry, scaly skin to high levels of fat in the bloodstream, the drug is believed to have triggered hundreds of birth defects when it was taken by pregnant women during the early 1980s...
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