Word: jacobey
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...John Arthur Jacobey started from the premise that if the heart has time, it can, in many if not most cases, repair itself. Back of this premise is the fact that post-mortem examinations, after deaths from other causes than heart at tacks, frequently reveal gradual coronary-artery shutdowns, which developed so slowly that smaller, collateral artery branches grew and took over the work of the closing artery...
...when the through roads are open. Unfortunately, it is immediately after an attack that the heart is least able to use the side-street arteries: the blood pressure is low, and it takes above-normal pressure to open promptly the narrow, neglected collaterals. The time to do this, Dr. Jacobey concluded, is in the intervals (diastole) between heart contractions...
...Jacobey and colleagues began by giving dogs standardized heart attacks by injecting plastic pellets into their coronaries. Five out of six dogs died. Then they hooked up six other dogs, also given heart attacks, to a small, simple pump that is timed by the electrocardiograph. When the heart contracts, the pump is relaxed and actually withdraws a little blood. When the heart relaxes, the pump gets in its "beat"' and forces blood through the aorta into the coronary arteries. After two hours on the pump, five out of these six dogs lived...
...Jacobey explained that 1) the pump reduces the heart's work when it has just been damaged and its condition is most critical, 2) it increases the flow through all coronary vessels, but 3) it causes the greatest increase in the formerly dormant collateral branches...
...patients must be hooked up promptly, within hours after the heart attack, and are kept on the machine for two hours. Of the results obtained so far, Dr. Jacobey would say only that they have been "encouraging...