Word: jama
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...study, published in today’s Journal of the American Medical Association (JAMA), sampled 305,000 members of various health care plans. Each subject was over...
Sources: Good News--Archives of Internal Medicine. Bad News--JAMA; New England Journal of Medicine
...their part, the drug manufacturers stand firmly behind their products. Merck says its own meta-analysis, which contains data that weren't included in the JAMA study, shows that Vioxx is safe for the heart. Others have focused on the study's admitted limitations, including its direct comparisons of dissimilar patient groups. Says Dr. Michael Friedman, a senior vice president of Pharmacia: "The JAMA article is based on theory, not on solid data...
...meta-analysis, published in last week's Journal of the American Medical Association, showed that those who took COX-2 inhibitors suffered slightly more heart attacks than those who took older, aspirin-like drugs. The authors considered several explanations. Since the older drugs help prevent heart disease, the JAMA study might only be picking up the absence of a protective effect in the COX-2 inhibitors. Or the new painkillers might actually promote the creation of blood clots. Or both processes might be at work. The point, Topol says, is that "the cardiovascular effects of the [COX-2 inhibitors...
Sources: Good News--JAMA (8/15/01); National HIV Prevention Conference (8/14/01). Bad News--New England Journal of Medicine (8/16/01); NEJM Online (8/14/01...