Word: jamas
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...address those concerns, researchers at the CDC and the FDA, which keep track of adverse events related to vaccines once they are approved, now report in the Journal of the American Medical Association (JAMA) that the rate of adverse events associated with the 23 million doses of Gardasil administered since 2006 is similar to the prelicensing rate among the 21,000 girls and young women who tested it in clinical trials and to that of other vaccines...
...that uncertainty that is beginning to bother many physicians about the HPV vaccine. According to Dr. Charlotte Haug, editor in chief of the Journal of the Norwegian Medical Association and author of an editorial that JAMA published alongside Slade's paper, cervical cancer can be effectively picked up with Pap smears, a routine part of regular gynecological exams, and it's not clear that adding Gardasil to those screenings would significantly reduce a woman's chance of developing the disease...
...study published on June 16 in the Journal of the American Medical Association (JAMA) now threatens to send researchers back to the drawing board. The meta-analysis of 14 prior studies concludes that the so-called depression gene - a variant of a serotonin-transporter gene called 5-HTTLPR - may not be associated with an elevated risk for depression, as many researchers had believed. "Knowing whether or not you have this gene is irrelevant," says the study's co-author Kathleen Merikangas, a genetic epidemiologist at the National Institute of Mental Health, who adds that future studies of genetic risk factors...
...JAMA study, which reviewed 14 studies involving 14,250 participants on the interaction between the serotonin-transporter gene and stressful life events, found no such association with depression risk. The study goes on to caution that any potential use of 5-HTTLPR as a screening tool for depression risk would be invalid. Currently, no such test exists, although several genetic-testing companies, including 23andME and Navigenics, do use genetic markers to tell customers which antidepressant drugs they are more likely to respond...
...Meta-analyses can be a steamroller," says Alexandre Todorov, a genetic epidemiologist at Washington University in St. Louis, Mo., whose 2007 peer-reviewed study was included in the JAMA piece. (While Todorov's study found an association between the gene and depression, it was based on a different variant - the long allele as opposed to the short one.) "If you have three studies and two find nothing and the third finds something significant, that does not mean that the third study is not real...