Word: joslin
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Dates: during 1950-1959
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Side Effects. About there the agreement ended. Dr. Robert F. Bradley Jr. of Boston's famed Joslin Clinic, reporting on 1,000 patients intensively studied, said tolbutamide gave good control in 55% and fair control in 14%. For chlorpropamide and metahexamide, the proportions were about the same-but not the patients: some who did poorly on tolbutamide responded to one of the other drugs, and a few who failed on two responded to the third. There was no denying that side effects (skin rashes, nausea, vomiting, heartburn) were more common with chlorpropamide and metahexamide, and there were...
...biguanides, the Joslin Clinic's Dr. Leo P. Krall conceded (after trial in 244 patients) that they "are capricious unless the physician uses them with special understanding." But he insisted that DBI, given along with reduced doses of insulin, has helped some unstable diabetics to lead a more normal life than they could when they took insulin several times a day. Main trouble: there is a narrow margin of safety between the DBI dose needed to control the blood sugar level and the dose that may produce side effects, so treatment in severe cases should begin in a hospital...
...have done much to help their fellows live longer useful lives are physicians who now share the benefits. Boston's Dr. Elliott Proctor Joslin, 91, top authority on diabetes, still examines patients six days a week at the famed Joslin Clinic, gets a big extra dividend from continuing practice because no other man has studied diabetes, or the same patients, for so long. Retired in Florida after 57 years of practice, Dr. Charles Ward Crampton, 81, still keeps his hand in as a consultant to the Geriatric Institute at the University of Miami's School of Medicine...
...next Crimson try was disallowed for offsides, but five minutes later John Chalsty made good use of a dropped Yale pass to make it 11 to 0, then Joslin converted an easy penalty kick from an Eliscrum infringement in front of the posts, giving the Crimson a 14 to 0 lead...
After winger Mike Reynal had been stopped just short of the line, fullback Jim Damis came up to take a pass from Hal Churchill for the final Crimson try. Joslin's kick again was good...