Word: journals
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Dates: during 2000-2009
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...stole the books he read, attended poetry readings only to shout down those he disdained, and led an outlaw band of avant-garde poets. This is the life he idealizes in “The Savage Detectives.” The semi-autobiographical novel begins with a series of journal entries by Juan García Madero, a 17-year-old law school dropout who falls in with a group of poets calling themselves the “visceral realists” (the fictional counterparts to Bolaño’s “infrarealists”). Garc?...
Tucker is editorial-page editor of the Atlanta Journal-Constitution
...against cancer, and a goal hotly pursued by researchers around the world. Bendandi and his colleagues at Spain's Center for Applied Medical Research and the University of Navarre Hospital have gone farther than most. In a five-year-long study - its results were described as "remarkable" by the Journal of the National Cancer Institute which published the report last September - the Pamplona-based group demonstrated that a customized vaccine could extend, perhaps indefinitely, the cancer-free period for patients with follicular lymphoma. In the wake of that success, Bendandi is preparing another study, one with an even more ambitious...
...testing of custom-made vaccines would be meaningless because each patient in the experimental arm receives a different treatment. So he set about proving efficacy in another way. "The course of the study design was the first innovation," writes Dr. Dan Longo in an editorial appearing in the same journal that published Bendandi's study. "Each patient would be his or her own control. Second remissions longer than first would be an indication of therapeutic effect...
...everyone is convinced by that logic. Dr. Robert Schwartz, an editor at the New England Journal of Medicine, says, "Using patients as their own control is a bit shaky, especially for follicular lymphoma." A Phase III randomized trial, more difficult but still possible to conduct even with customized vaccines remains, he says, "the gold standard for proof of efficacy." Dr. Kwak, who is conducting his own Phase III trial of a vaccine for the American pharmaceutical company Biovest, believes his former trainee's results support the case for a therapeutic lymphoma vaccine, but is skeptical about his methods. "Dr. Bendandi...