Word: kalman
(lookup in dictionary)
(lookup stats)
Dates: during 1960-1969
Sort By: most recent first
(reverse)
Such stereotyped prescribing is extremely unsound, says Pharmacologist Sumner Kalman of Stanford University. "There is no average man who always needs a particular dose of this or that drug on a certain daily schedule," Dr. Kalman notes. Even patients who are identical in sex and size do not absorb a drug into the bloodstream at the same rate. Their systems do not metabolize the drug at the same rate. Moreover, their reactions to a drug may range all the way from nil to collapse and sudden death as a result of severe allergic shock. "The fate of a drug...
Across Ethnic Lines. The need for such procedures is being emphasized by a growing body of biochemical knowledge. "As a patient's health changes, or as other drugs are used," says Kalman, "the blood level of an important drug may change." One example is the use of barbiturates in combination with digitalis. If a patient is on digitoxin, one of the digitalis products, and then uses barbiturates for a while, his heart-medicine dosage should be checked, and possibly adjusted, twice. Barbiturates speed up the metabolism of digitalis-type drugs, which are critical within a narrow range. Even...
Precise drug dosages for individuals are undoubtedly years off, for Kalman's is a counsel of pharmacological perfection. Nonetheless, he and two fellow pharmacologists at Stanford, Drs. Avram Goldstein and Lewis Aronow, have given it considerable impetus with their exhaustive, 884-page study, Principles of Drug Action (Hoeber Medical Division of Harper & Row). The differences among patients in their reactions to drugs may be caused by race, individual heredity, personal idiosyncrasy, or allergic reaction. Enzyme deficiencies and abnormal hemoglobins are found among Negroes and some Mediterranean peoples. In as many as 10% of Negro males, normal doses...
...certain drug. "Patients are commonly unaware of what medication they receive, multiple irrational drug mixtures abound, and memories tend to be much less persistent than antibody-forming capacity." Reaction to penicillin injections cause an estimated 100 deaths annually in the U.S. What is most tragic about these deaths, say Kalman and his colleagues in citing a number of cases, is that the penicillin was injected for a sprained tee, an injured finger, and mild upper respiratory infections. "Penicillin could have served no useful purpose in these instances...
...found her destiny. At 39, she is the New York City Opera's prima donna and clearly ranks as one of the two or three finest coloraturas in the world. At the New York Phil harmonic Promenade Concert, she sings a selection of Viennese arias and songs by Kalman, Korngold, Mozart and Richard Strauss, displaying a faultless voice that sweeps with elaborate embellishments to feathery, accurate high notes. The audience goes wild and demands an encore. From Santiago, Buenos Aires, Vienna and London come frantic pleas for concerts. Backstage, greeting her well-wishers, Beverly sings the obligatory arioso...