Word: kamb
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...cancer cells -- but conspicuously absent from most normal cells. If cancer researchers can find a way to deactivate this enzyme, known as telomerase, they may at last have the magic bullet they have long been seeking. Equally tantalizing was the article published in Science by molecular biologist Alexander Kamb and his colleagues at Myriad Genetics, a Salt Lake City, Utah, biotech firm. A majority of cancer cells, they found, lack functioning copies of a gene that serves as a circuit breaker and shuts down the abnormal cell growth that causes malignancy. Already Kamb is dreaming up ways to fix this...
Until last week, p53, the subject of some 1,000 scientific papers in 1993 alone, was considered the most important cancer gene. The journal Science even named it Molecule of the Year. But now there is a new contender for notoriety -- MTS1, as Alexander Kamb and his colleagues refer to the multiple tumor- suppressor gene they have just discovered. "Multiple" refers to the fact that defects in this gene can cause many kinds of cancer, including melanoma, lung, breast and brain tumors. In fact, functional copies of MTS1 may be missing in more than 50% of all human cancers...
...decision to divide are spurring particular interest. The protein made by the MTS1 gene seems exceptionally promising, for it has characteristics suggesting it may be easily fashioned into a drug, which then might be able to stop tumor cells in their tracks. "In terms of therapeutic potential," declares Kamb, "MTS1 may be the most important tumor-suppressor gene yet discovered...
Also included are David Garfinkel 1G, biochemistry; David M. Geller 1G, biochemistry; Walter Gilbert '53, physics; Richard B. Hiatt 1G, chemistry; John R. Hughes 1G, psychology; Peter M. Kamb 1G, botany; Ralph W. Kilb 1G, chemistry; Joshua K. Kopp '53, physics; Paul H. Kydd 1G, chemistry; Francis L. Lambert 1G, zoology; Henry J. Landau '53, mathematics; Andrew D. Liehr 1G, physics; Robert D. Lundberg, chemistry; and James C. Martin 1G, chemistry...
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